100121-60-6

Basic information

• Product Name: 1-(2-acetyl-phenyl)-butan-1-one
• CAS NO: 100121-60-6
• Molecular Weight: 190.242
• Mol File: 100121-60-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-acetyl-phenyl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-acetyl-phenyl)-butan-1-one(100121-60-6)
• EPA Substance Registry System: 1-(2-acetyl-phenyl)-butan-1-one(100121-60-6)

Safety Data

• Hazardous Substances Data: 100121-60-6(Hazardous Substances Data)

Upstream product

• 2142-70-3 2-iodoacetophenone 
• 123-72-8 butyraldehyde 
• 35028-12-7 1-(2-ethyl-phenyl)-butan-1-one 

Downstream Products

• 5409-32-5 2-ethyl-1,4-naphthoquinone 
• 29366-44-7 2-ethyl-3-hydroxy-[1,4]naphthoquinone 

Relevant articles and documents

Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones

A sequential one-pot strategy for the diversified synthesis of phthalazines, phthalazinones and benzoxazinones was presented. This strategy proceeds through [Pd]-catalyzed acylation and nucleophilic cyclocondensation with dinucleophilic reagents. This process was based on direct coupling with simple bench-top aldehydes without the assistance of directing group and without activating the carbonyl group. The process is highly advantageous because it employs simple nitrogen-based nucleophiles, and non-toxic and readily accessible aldehydes as the carbonyl source. Most importantly, the strategy was applied to the one-pot synthesis of PDE-4 inhibitor.