1001258-95-2Relevant academic research and scientific papers
Total synthesis of diverse carbogenic complexity within the resveratrol class from a common building block
Snyder, Scott A.,Breazzano, Steven P.,Ross, Audrey G.,Lin, Yunqing,Zografos, Alexandras L.
supporting information; experimental part, p. 1753 - 1765 (2009/07/25)
Although biomimetic approaches have proven capable of converting resveratrol (1) concurrently into many of the more complex oligomers produced by plants throughout the world (such as 2-10), methods to access single members of the family have proven far more difficult to identify. Herein is described a strategy-level solution based on the use of a common building block, one distinct from Nature's starting material, that can participate in a variety of highly selective, reagent-controlled reaction cascades. These endeavors have led to the controlled synthesis of 25 natural products and analogues, molecules whose architectures encompass nearlyall the carbogenic diversity of the resveratrol family.
Total synthesis of resveratrol-based natural products: A chemoselective solution
Snyder, Scott A.,Zografos, Alexandros L.,Lin, Yunqing
, p. 8186 - 8191 (2008/09/18)
Despite the attention paid to resveratrol (1) owing to its potent biological activity, little effort has been devoted to studying resveratrol-based oligomers (such as 2-4). The first general synthetic approach is outlined for accessing the carbogenic diversity possessed by this family of compounds. (Chemical Equation Presented).
