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1001270-26-3

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1001270-26-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1001270-26-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,2,7 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1001270-26:
(9*1)+(8*0)+(7*0)+(6*1)+(5*2)+(4*7)+(3*0)+(2*2)+(1*6)=63
63 % 10 = 3
So 1001270-26-3 is a valid CAS Registry Number.

1001270-26-3Downstream Products

1001270-26-3Relevant articles and documents

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

Donovan, Katherine A.,Eleuteri, Nicholas A.,Erickson, Emily C.,Fischer, Eric S.,Gray, Nathanael S.,Toker, Alex,You, Inchul

, p. 66 - 73 (2020)

The PI3K/AKT signaling cascade is one of the most commonly dysregulated pathways in cancer, with over half of tumors exhibiting aberrant AKT activation. Although potent small-molecule AKT inhibitors have entered clinical trials, robust and durable therape

DEGRADATION OF AKT BY CONJUGATION OF ATP-COMPETITIVE AKT INHIBITOR GDC-0068 WITH E3 LIGASE LIGANDS AND METHODS OF USE

-

, (2020/10/21)

Disclosed are bifunctional compounds comprising a GDC-0068 analog that binds AKT isoforms AKT1, 2 and 3, pharmaceutical compositions, and methods for treating diseases or conditions mediated by dysfunctional AKT activity.

COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE

-

, (2012/10/18)

The invention provides a combination of a) a compound of Formula Ia: [insert Formula Ia], or a pharmaceutically acceptable salt thereof, and b) vemurafenib or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic treatment of a hy

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