1001318-01-9Relevant academic research and scientific papers
Green synthesis of fused pyrimido derivatives in aqueous medium
Kidwai, Mazaahir,Singhal, Kavita
, p. 1253 - 1257 (2008/09/18)
(Chemical Equation Presented) The synthesis of nitrogen containing heterocycles from arylidene barbituric acid and various ammonia derivatives such as phenylhydrazine hydrochloride, hydroxylamine hydrochloride and aminoguanidine hydrochloride via a simple and efficient cyclocondensation in an alkaline aqueous medium is described. This improved greener synthetic methodology provides a convenient direct approach using water as a green solvent and potassium carbonate (K2CO3) as a green base for the synthesis of pyrazolopyrimidines, isoxazolopyrimidines and pyrimidopyrimidines in excellent yields.
