100133-00-4Relevant academic research and scientific papers
Methods and compositions for treating amyloid-related diseases
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Page/Page column 178, (2010/11/24)
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
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, (2008/06/13)
The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.
PCP receptor and dopamine uptake sites are discriminated by chiral TCP and BTCP derivatives of opposite configuration
Coderc, E.,Cerruti, P.,Vignon, J.,Rouayrenc, J. F.,Kamenka, J. M.
, p. 463 - 470 (2007/10/02)
3-Methylpiperidine derivatives of 1-piperidine (TCP) and 1-thiophenyl)cyclohexyl>piperidine (BTCP) were obtained in their racemic and homochiral forms.They have been tested for their affinity for the K receptor label
Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues
Thurkauf, Andrew,Costa, Brian de,Yamaguchi, Shun-ichi,Mattson, Mariena V.,Jacobson, Arthur E.,et al.
, p. 1452 - 1458 (2007/10/02)
Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.
