100133-05-9Relevant academic research and scientific papers
Gold complex containing diphosphine ortho-position carborane ligand as well as preparation method and application of gold complex
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Paragraph 0032; 0036-0040, (2020/07/21)
The invention relates to a gold complex containing a diphosphine ortho-position carborane ligand as well as a preparation method and an application of the gold complex. The gold complex is prepared bythe following method: dropwise adding an n-BuLi solutio
A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability
Kim, Junwon,Ok, Taedong,Park, Changmin,So, Wonyoung,Jo, Mina,Kim, Youngmi,Seo, Minjung,Lee, Doohyun,Jo, Suyeon,Ko, Yoonae,Choi, Inhee,Park, Youngsam,Yoon, Jaewan,Ju, Moon Kyeong,Ahn, Jiye,Kim, Junghwan,Han, Sung-Jun,Kim, Tae-Hee,Cechetto, Jonathan,Nam, Jiyoun,Liuzzi, Michel,Sommer, Peter,No, Zaesung
, p. 2522 - 2526 (2012/05/05)
Following the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM) scaffold is described. Replacement of the ester moiety by thiazole ring significantly improved the metabolic stability while retaining antiviral activity against HIV-1 replication. These novel and potent DHPMs with bioisosteres could serve as advanced leads for further optimization.
ANTI VIRAL COMPOUNDS
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Page/Page column 170, (2010/05/13)
There is provided small molecule anti-human immunodeficiency virus (anti-HIV) compounds as well as a phenotypic cell-based high throughput screening (HTS) assay for their identification.
