1001433-48-2Relevant academic research and scientific papers
MTKI QUINAZOLINE DERIVATIVES
-
Page/Page column 30, (2010/03/02)
The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y represents —C3-9alkyl-, —C1-5alkyl-NR6—C1-5alkyl- or —C1-5alkyl-NR7—CO—C1-5alkyl-;X1 represents —O—;X2 represents NR5—C1-2alkyl-;R1 represents hydrogen, halo or Het3-O—;R2 represents hydrogen;R3 represents hydroxy, C1-4alkyloxy- or C1-4alkyloxy substituted with one or two substituents each independently selected from Het4, hydroxy, C1-4alkyloxy-, C1-4alkyloxy-C1-4alkyloxy and NR9R10;R5 represents hydrogen or C1-4alkyl;R6 represents hydrogen or C1-4alkyl;R7 represents hydrogen;R9 and R10 each independently represent hydrogen; C1-4alkyl-S(═O)2—C1-4alkyl-C(═O)—; C1-4alkyl or C1-4alkyl substituted with hydroxy;Het3 represents pyridinyl optionally substituted with C1-4alkyl;Het4 represents morpholinyl, piperidinyl or piperazinyl wherein said Het4 is optionally substituted with hydroxy-C1-4alkyl or C1-4alkyl-S(═O)2—C1-4alkyl-.
