1001735-55-2Relevant academic research and scientific papers
4-Aminoantipyrine-based Schiff-base transition metal complexes as potent anticonvulsant agents
Kurdekar, Gurunath S.,Sathisha,Budagumpi, Srinivasa,Kulkarni, Naveen V.,Revankar, Vidyanand K.,Suresh
, p. 2273 - 2279 (2012)
Metal complexes of Co(II), Ni(II), Cu(II), and Zn(II) with ligands (L 1H and L2) derived from 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin were synthesized and characterized by the elemental analysis, conductance measurements, magnetic susceptibility, and spectral analysis. The spectral data revealed that the ligands acted as a neutral tridentate, coordinating to the metal ion through the azomethine nitrogen, phenolic oxygen, and carbonyl oxygen of the 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin molecule in ligands L1H and L2 only. Both the ligands and their metal complexes were studied for cyclic voltammetry studies. The ligand and the metal complexes were screened for their anticonvulsant activity, and it has been observed that the metal complexes are more potent than the ligands. Springer Science+Business Media, LLC 2011.
Synthesis of a New Series of N-Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases
Afsah, Elsayed M.,Fadda, Ahmad A.,Hanash, Ahlam H.
, p. 736 - 742 (2018/03/21)
The reaction of isatin 1 with benzaldehyde and a sec-amine or the appropriate aldimine afforded the N-Mannich bases 2–3 and the bis-base 4. Treatment of 1 with glutaric dialdehyde and morpholine gave the bis-base 5. Mannich reaction of the Schiff bases 6a–f derived from 1, led to the new Mannich bases and bis-bases 7–9. The use of N-methyl-D-glucamine as the amine component in the Mannich reaction with 6b–f led to the polyhydroxy Mannich bases 11–13.
"On water" synthesis of spiro-indoles via Schiff bases
Panda, Siva S.,Jain, Subhash C.
experimental part, p. 1187 - 1194 (2012/09/25)
A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic am
A facile synthesis of novel spiro-[indole-pyrazolinyl-thiazolidine]-2,4′-dione
Jain, Subhash C.,Sinha, Juhi,Bhagat, Sunita,Errington,Olsen, Carl E.
, p. 563 - 577 (2007/10/03)
A reaction of appropriate indol-2,3-diones with 4-aminoantipyrine has resulted in the formation of hitherto unknown 3-(2,3-dimethyl-5-oxol-phenyl-3-pyrazolin-4-yl-imino)-indol-2- ones in quantitative yields which upon cyclocondensation with mercaptoacetic acid afforded a series of new spiro heterocycles 3'-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) spiro[3H-indol-3,2'-thiazolidine]-2,4'-diones.
Synthesis of Some 4-(1,5-Disubstituted-2-oxoindolinylideneimino)-2,3-dimethyl-1-phenyl-δ3-pyrazolin-5-ones as Possible Pesticides
Sengupta, Anil K.,Gupta, Anurag Ateet
, p. 72 - 74 (2007/10/02)
Several new 4-(1,5-disubstituted-2-oxoindolinylideneimino)-2,3-dimethyl-1-phenyl-Δ3-pyrazolin-5-ones (IIIa-c and IVa-c) have been synthesised and their structures assigned on the basis of analytical and spectral (IR, PMR) data.Their insecticidal, antibacterial and antifungal activities have also been studied.
