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1001756-21-3

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1001756-21-3 Usage

General Description

4-amino-6-chloronicotinaldehyde is a chemical compound with the molecular formula C6H5ClN2O. It is a derivative of nicotinaldehyde, and its structure consists of a pyridine ring with an amino group at the 4 position and a chlorine atom at the 6 position. 4-amino-6-chloronicotinaldehyde is used in organic synthesis and pharmaceutical research. It has been studied for its potential medicinal properties, particularly as an anti-tuberculosis agent. Additionally, it has been investigated for its potential use in the development of fluorescent probes for biological imaging. 4-amino-6-chloronicotinaldehyde has also been found to have antibacterial and antifungal properties, making it a valuable compound in various scientific and industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1001756-21-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,7,5 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1001756-21:
(9*1)+(8*0)+(7*0)+(6*1)+(5*7)+(4*5)+(3*6)+(2*2)+(1*1)=93
93 % 10 = 3
So 1001756-21-3 is a valid CAS Registry Number.
InChI:InChI=1S/C6H5ClN2O/c7-6-1-5(8)4(3-10)2-9-6/h1-3H,(H2,8,9)

1001756-21-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Amino-6-chloronicotinaldehyde

1.2 Other means of identification

Product number -
Other names 4-amino-6-chloropyridine-3-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001756-21-3 SDS

1001756-21-3Relevant articles and documents

CHEMICAL COMPOUNDS AS H-PGDS INHIBITORS

-

, (2019/01/08)

A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells

Henry, James R.,Kaufman, Michael D.,Peng, Sheng-Bin,Ahn, Yu Mi,Caldwell, Timothy M.,Vogeti, Lakshminarayana,Telikepalli, Hanumaiah,Lu, Wei-Ping,Hood, Molly M.,Rutkoski, Thomas J.,Smith, Bryan D.,Vogeti, Subha,Miller, David,Wise, Scott C.,Chun, Lawrence,Zhang, Xiaoyi,Zhang, Youyan,Kays, Lisa,Hipskind, Philip A.,Wrobleski, Aaron D.,Lobb, Karen L.,Clay, Julia M.,Cohen, Jeffrey D.,Walgren, Jennie L.,McCann, Denis,Patel, Phenil,Clawson, David K.,Guo, Sherry,Manglicmot, Danalyn,Groshong, Chris,Logan, Cheyenne,Starling, James J.,Flynn, Daniel L.

, p. 4165 - 4179 (2015/06/08)

The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical efficac

RAF INHIBITOR COMPOUNDS

-

, (2013/09/26)

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

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