1001756-23-5

Basic information

• Product Name: Methyl 7-broMoquinoline-3-carboxylate
• Synonyms: Methyl 7-broMoquinoline-3-carboxylate
• CAS NO: 1001756-23-5
• Molecular Formula: C₁₁H₈BrNO₂
• Molecular Weight: 266.09072
• Mol File: 1001756-23-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 348.5±22.0 °C(Predicted)
• Appearance: /
• Density: 1.557±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.53±0.25(Predicted)
• CAS DataBase Reference: Methyl 7-broMoquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 7-broMoquinoline-3-carboxylate(1001756-23-5)
• EPA Substance Registry System: Methyl 7-broMoquinoline-3-carboxylate(1001756-23-5)

Safety Data

• Hazardous Substances Data: 1001756-23-5(Hazardous Substances Data)

Usage

General Description

Methyl 7-bromquinoline-3-carboxylate is a chemical compound with the molecular formula C11H8BrNO2. It is a derivative of quinoline, a heterocyclic aromatic organic compound. Methyl 7-broMoquinoline-3-carboxylate is commonly used in organic synthesis as a building block for the preparation of various complex molecules, such as pharmaceuticals and agrochemicals. It is known for its versatile reactivity and is often used in the development of new drugs and materials. Methyl 7-bromquinoline-3-carboxylate has also been studied for its potential biological activities and pharmacological properties, making it a valuable tool in medicinal chemistry research.

Upstream product

• 1416560-86-5 C₁₈H₁₈BrNO₄S 
• 500163-43-9 2-[(3-bromo-phenyl)-hydroxy-methyl]-acrylic acid methyl ester 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1020567-86-5 methyl (2E)-3-(4-bromophenyl)-2-({[(4-methylphenyl)sulfonyl]amino}methyl)-2-propenoate 

Downstream Products

• 1276656-22-4 methyl 7-(4-hydroxyphenyl)quinoline-3-carboxylate 
• 1020567-77-4 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid 
• 1020567-95-6 methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate 

Relevant articles and documents

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

In methods employing molecular probes to explore the targets of bioactive small molecules, long or rigid linker moieties are thought to be critical factors for efficient tagging of target protein. We previously reported the synthesis of a jasmonate glucoside probe with a highly rigid linker consisting of a triazoyl-phenyl (TAzP) moiety, and this probe demonstrated effective target tagging. Here we compare the TAzP probe with other rigid or flexible probes with respect to target tagging efficiency, hydrophobic parameters, aqueous solubility, and dihedral angles around the biaryl linkage by a combination of empirical and calculation methods. The rigid biaryl linkage of the TAzP probe has a skewed conformation that influences its aqueous solubility. Such features that include rigidness and good aqueous solubility resulted in highly efficient target tagging. These findings provide a promising guideline toward designing of better linkers for improving molecular probe performance.