1001857-41-5Relevant academic research and scientific papers
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
Coleman, Paul J.,Schreier, John D.,Roecker, Anthony J.,Mercer, Swati P.,McGaughey, Georgia B.,Cox, Christopher D.,Hartman, George D.,Harrell, C. Meacham,Reiss, Duane R.,Doran, Scott M.,Garson, Susan L.,Anderson, Wayne B.,Tang, Cuyue,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
scheme or table, p. 4201 - 4205 (2010/08/22)
Orexins are excitatory neuropeptides that regulate arousal and sleep. Orexin receptor antagonists promote sleep and offer potential as a new therapy for the treatment of insomnia. In this Letter, we describe the synthesis of constrained diazepanes having
BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS
-
Page/Page column 43; 44, (2008/06/13)
The present invention is directed to bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. T
