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1001922-15-1

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1001922-15-1 Usage

Description

Methyl 2-bromo-3-(4'-fluorophenyl)-3-oxopropanoate, also known as MFPBO, is a chemical compound with the molecular formula C11H9BrFO3. It is a valuable tool in organic synthesis and has potential applications in the pharmaceutical industry.

Uses

Used in Organic Synthesis:
MFPBO is used as a reagent in organic synthesis for the preparation of various other organic compounds. Its unique structure and functional groups make it a versatile building block for creating a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, MFPBO is used as a building block for the synthesis of biologically active molecules. Its potential applications in drug development make it an important compound for the creation of new drugs and other important organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 1001922-15-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,9,2 and 2 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1001922-15:
(9*1)+(8*0)+(7*0)+(6*1)+(5*9)+(4*2)+(3*2)+(2*1)+(1*5)=81
81 % 10 = 1
So 1001922-15-1 is a valid CAS Registry Number.

1001922-15-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-bromo-3-(4-fluorophenyl)-3-oxopropanoate

1.2 Other means of identification

Product number -
Other names I01-8774

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001922-15-1 SDS

1001922-15-1Relevant articles and documents

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Joncour, Agnès,Desroy, Nicolas,Housseman, Christopher,Bock, Xavier,Bienvenu, Natacha,Cherel, La?titia,Labeguere, Virginie,Peixoto, Christophe,Annoot, Denis,Lepissier, Luce,Heiermann, J?rg,Hengeveld, Willem Jan,Pilzak, Gregor,Monjardet, Alain,Wakselman, Emanuelle,Roncoroni, Veronique,Le Tallec, Sandrine,Galien, René,David, Christelle,Vandervoort, Nele,Christophe, Thierry,Conrath, Katja,Jans, Mia,Wohlkonig, Alexandre,Soror, Sameh,Steyaert, Jan,Touitou, Robert,Fleury, Damien,Vercheval, Lionel,Mollat, Patrick,Triballeau, Nicolas,Van Der Aar, Ellen,Brys, Reginald,Heckmann, Bertrand

, p. 7371 - 7392 (2017)

Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industry as it has been implicated in several diseases including cancer, fibrotic diseases, and inflammation, among others. An imidazo[1,2-a]pyridine series of ATX inhibitors was identified out of a high-throughput screening (HTS). A cocrystal structure with one of these compounds and ATX revealed a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction with zinc ions of the catalytic site. Exploration of the structure-activity relationship led to compounds displaying high activity in biochemical and plasma assays, exemplified by compound 40. Compound 40 was also able to decrease the plasma LPA levels upon oral administration to rats.

METHODS FOR INHIBITING CASEIN KINASES

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Paragraph 00192-00194, (2021/10/02)

The present disclosure provides methods for inhibiting CK1 delta or CK1 epsilon activity, comprising administering an effective amount of the compound of Formula (I) to (IV), or a pharmaceutically acceptable salt thereof.

Synthesis and biological activity of imidazopyridine anticoccidial agents: Part I

Scribner, Andrew,Dennis, Richard,Hong, Jean,Lee, Shuliang,McIntyre, Donald,Perrey, David,Feng, Dennis,Fisher, Michael,Wyvratt, Matthew,Leavitt, Penny,Liberator, Paul,Gurnett, Anne,Brown, Chris,Mathew, John,Thompson, Donald,Schmatz, Dennis,Biftu, Tesfaye

, p. 1334 - 1357 (2008/09/17)

Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance

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