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10021-63-3

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10021-63-3 Usage

General Description

(R)-2-Hydroxypentanenitrile, also known as (R)-2-Hydroxy-Valeronitrile, is a chemical compound with the molecular formula C5H9NO. It is a colorless to pale yellow liquid with a fruity odor and is used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a chiral building block for the synthesis of various compounds. (R)-2-Hydroxypentanenitrile has a boiling point of 167-168°C and is soluble in water, ethanol, and diethyl ether. It is important to handle this chemical with caution as it may cause irritation to the skin, eyes, and respiratory system and can be harmful if ingested or inhaled in large amounts.

Check Digit Verification of cas no

The CAS Registry Mumber 10021-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,2 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10021-63:
(7*1)+(6*0)+(5*0)+(4*2)+(3*1)+(2*6)+(1*3)=33
33 % 10 = 3
So 10021-63-3 is a valid CAS Registry Number.

10021-63-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-(+)-2-hydroxypentanenitrile

1.2 Other means of identification

Product number -
Other names (R)-2-Hydroxypentanenitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10021-63-3 SDS

10021-63-3Relevant articles and documents

Difficult substrates in the R-hydroxynitrile lyase catalyzed hydrocyanation reaction: Application of the mass transfer limitation principle in a two-phase system

Gerrits, Pieter J.,Marcus, Jan,Birikaki, Lemonia,Van der Gen, Arne

, p. 971 - 974 (2001)

The application of a number of new and/or difficult substrates in the catalyzed hydrocyanation reaction by R-hydroxynitrile lyase from almonds is described. By using an aqueous-organic two-phase system and increasing the rate of the enzymatic reaction relative to the mass transfer rate, the enantiomeric purity was improved. By fine tuning the reaction parameters (temperature, pH, and the amount of enzyme) the hydrocyanation reaction was optimized for all substrates. The general principles described here can also be applied to optimize the reaction conditions for other substrates.

Enzymatic Resolution of Optically Active Aliphatic Cyanohydrins

Kanerva, Liisa T.,Kiljunen, Eero,Huuhtanen, Tuomas T.

, p. 2355 - 2362 (1993)

Enantioselective acylation of cyanohydrins 1a-9a by PPL catalysis and deacylation of propionates 1b-9b by CCL catalysis in toluene from good (E 15-20) to excellent (E >30) enantioselectivity.A solvent has a clear effect on enzymatic enantioselectivity.

A simple separation method for (S)-hydroxynitrile lyase from cassava and its application in asymmetric cyanohydrination

Zheng, Zubiao,Zi, Yan,Li, Zhongzhou,Zou, Xinzhuo

, p. 434 - 439 (2013/06/27)

Using an acetone precipitation method, crude (S)-hydroxynitrile lyase [(S)-MeHNL] was separated from Munihot esculenta (cassava) leaves, and used directly as biocatalyst to catalyze asymmetric cyanohydrination and produce cyanohydrins with enantiomeric purities (≥90% ee) significantly greater than those previously reported. The use of a water/i-Pr2O system with an enzyme, NaCN, and appropriate amounts of acetic acid is crucial in improving the stereoselectivity of cyanohydrin formation by minimizing the non-enzymatic reaction and the racemization of the chiral products. The proposed isolation method for crude (S)-MeHNL has a high value because of its simplicity, and low cost as well as the high activity of the crude (S)-MeHNL.

Stereoselective synthesis of β-amino-γ-butyrolactones

Roos, Juergen,Effenberger, Franz

, p. 1855 - 1862 (2007/10/03)

A novel synthesis of optically active β-amino-γ-butyrolactones is described. O-Silylated (R)-cyanohydrins (R)-3 (derived from aldehydes 1 by (R)-hydroxynitrile lyase ((R)-PaHNL)-catalyzed addition of HCN) were reacted with allyl Grignard to give amino alc

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