1002127-66-3

Upstream product

• 1002127-64-1 (Z)-3-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol 
• 104-53-0 3-phenyl-propionaldehyde 
• 455-13-0 4-Iodobenzotrifluoride 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 152876-60-3 ethyl (2Z)-3-iodo-3-phenylprop-2-enoate 
• 536-74-3 phenylacetylene 

Downstream Products

• 1002127-68-5 (2E,4Z)-5-Phenyl-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoic acid 
• 1002123-88-7 (2E,4Z)-N-(isoquinolin-5-yl)-5-phenyl-5-(4-trifluoromethylphenyl)-2,4-pentadienamide 
• 1002127-61-8 methyl (2E,4Z)-5-phenyl-5-(4-trifluoromethylphenyl)-2,4-pentadienoate 

Relevant academic research and scientific papers

Palladium-Catalyzed Cascade Saegusa–Heck Reaction: Synthesis of β,β-Diarylacroleins from Arylpropanals and Aryl Iodides

An efficient and convenient Pd-catalyzed Saegusa–Heck cascade protocol was developed, and its potential use in the synthesis of symmetrical and unsymmetrical β,β-diarylacroleins in moderate to high yields was investigated.

Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the phenyl ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b, which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mechanical allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.