1002202-35-8 Usage
Description
(2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide is a derivative of 2-propenamide, characterized by a phenyl group substituted with a methoxy group at the 3-position and a second phenyl group substituted with a methoxy group at the 4-position. (2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide, also known as (E)-N-(3-methoxyphenyl)-3-(4-methoxyphenyl)acrylamide, is utilized in organic synthesis and pharmaceutical research. Its unique structure and properties make it a valuable tool in drug discovery and development, with potential applications in mediating biological processes and interactions with proteins.
Uses
Used in Pharmaceutical Research:
(2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide is used as a research compound for its potential to mediate biological processes and interact with proteins. Its unique structure allows it to be a valuable tool in drug discovery and development, aiding in the design and synthesis of new pharmaceutical agents.
Used in Organic Synthesis:
In the field of organic synthesis, (2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide serves as a key intermediate or building block in the synthesis of more complex organic molecules. Its reactivity and functional groups make it suitable for various chemical reactions, contributing to the creation of new compounds with diverse applications.
Used in Drug Discovery:
(2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide is used as a starting material or a component in the development of new drugs. Its potential therapeutic applications are being investigated, which may lead to the discovery of novel treatments for various diseases and conditions.
Used in Chemical Research:
In chemical research, (2E)-3-(3-Methoxyphenyl)-N-(4-methoxyphenyl)-2-propenamide is employed to study its properties and reactivity. Understanding its behavior in different chemical environments can provide insights into the development of new synthetic methods and the creation of new chemical entities with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1002202-35-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,2,2,0 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1002202-35:
(9*1)+(8*0)+(7*0)+(6*2)+(5*2)+(4*0)+(3*2)+(2*3)+(1*5)=48
48 % 10 = 8
So 1002202-35-8 is a valid CAS Registry Number.
1002202-35-8Relevant articles and documents
Phenylcinnamides as novel antimitotic agents
Leslie, Benjamin J.,Holaday, Clinton R.,Nguyen, Tran,Hergenrother, Paul J.
supporting information; experimental part, p. 3964 - 3972 (2010/08/06)
Compound 8H is a phenylcinnamide that induces G2/M-phase cell cycle arrest and cell death in cancer cell lines. Here we show that 8H exerts its cytotoxic activity through disruption of microtubule dynamics in vitro and in cell culture. A series of cinnamide derivatives were synthesized and evaluated, and several new compounds were identified that improve on the activity of the parent compound, with IC50 values for induction of cell death ranging from 1 to 10 μM. Notably, these compounds retain potency in the HL-60/VCR leukemia cell line, which is resistant to antimitotic cancer drugs vincrisitine and paclitaxel through up-regulation of P-glycoprotein drug efflux pumps. As P-glycoprotein expression is often responsible for drug resistance in cancer and the exclusion of compounds from the central nervous system, 8H and its derivatives merit further examination as potential antimitotic therapeutics, specifically for brain cancers and cancers that are resistant to standard antimitotic agents.
