100223-11-8Relevant academic research and scientific papers
Chiral Rh phosphine-phosphite catalysts immobilized on ionic resins for the enantioselective hydrogenation of olefins in water
Kleman,Barbaro,Pizzano
supporting information, p. 3826 - 3836 (2015/07/15)
The asymmetric hydrogenation of prochiral enamides with Rh complexes bearing chiral phosphine-phosphite ligands (P-OP) supported on sulphonated polystyrene resins has been studied. The complexes have been supported by simple treatment of preformed [Rh(dio
Asymmetric chemoenzymatic synthesis of N-acetyl-α-amino esters based on lipase-catalyzed kinetic resolutions through interesterification reactions
Da Silva, Marcos Reinaldo,De Mattos, Marcos Carlos,De Oliveira, Maria Da Concei??o Ferreira,De Lemos, Telma Leda Gomes,Ricardo, Nágila Maria Pontes Silva,De Gonzalo, Gonzalo,Lavandera, Iván,Gotor-Fernández, Vicente,Gotor, Vicente
, p. 2264 - 2271 (2014/03/21)
Several phenylalanine analogs have been synthesized through a four-step route starting from easily available ethyl acetamidocyanoacetate. In a first reaction, and making use of phase transfer catalysts, this compound reacted with several alkyl halides, being benzyltributylammonium chloride identified as the best one for the production of a series of quaternary amino acids in moderate to excellent yields (52-95%). Then, the corresponding N-acetyl-phenylalanine methyl and allyl ester derivatives were obtained through acidic hydrolysis, esterification, and N-acetylation. Rhizomucor miehei lipase was found as a versatile enzyme for the resolution of these amino esters, finding the best results through interesterification reactions with butyl butyrate in acetonitrile. A great influence in the stereoselectivity was found depending on the chemical structure of the compound, achieving for the non- or para-substituted in the phenyl ring excellent stereoselectivities, being moderate for the meta-nitro derivative, while the ortho-nitro amino ester did not react.
Axial 4,4′,6,6′-tetrakis-trifluoromethyl-biphenyl-2, 2′diamine (TF-BIPHAM): Resolution and applications in asymmetric hydrogenation
Wang, Chun-Jiang,Gao, Feng,Liang, Gang
supporting information; experimental part, p. 4711 - 4714 (2009/05/31)
(Equation Presented) The racemic TF-BIPHAM was resolved for the first time, and the effectiveness of the resolved diamine was demonstrated by highly enantioselective hydrogenation of α-aryl enamides and α-dehydroamino acid esters using readily accessible
