1002564-71-7Relevant academic research and scientific papers
Model studies of β-scission ring-opening reactions of cyclohexyloxy radicals: Application to thermal rearrangements of dispiro-1,2,4-trioxanes
Erhardt, Stefan,Macgregor, Stuart A.,McCullough, Kevin J.,Savill, Karen,Taylor, Benjamin J.
, p. 5569 - 5572 (2007)
A DFT study of model cyclohexyloxy radicals (8a-c, 9) show that (a) the presence of an adjacent oxygen atom, and (b) α-substituents on the cyclohexyl ring, particularly methoxy, accelerate the rate of β-scission ring-opening reactions. Consistent with theoretical results, thermolysis of the methoxy-substituted dispiro-1,2,4-trioxane 10 afforded the structurally novel, 14-membered macrocyclic keto lactone 11 as the major isolable product.
