1002736-57-3Relevant academic research and scientific papers
1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
Tong, Yunsong,Claiborne, Akiyo,Pyzytulinska, Magdalena,Tao, Zhi-Fu,Stewart, Kent D.,Kovar, Peter,Chen, Zehan,Credo, Robert B.,Guan, Ran,Merta, Philip J.,Zhang, Haiying,Bouska, Jennifer,Everitt, Elizabeth A.,Murry, Bernard P.,Hickman, Dean,Stratton, Tim J.,Wu, Jian,Rosenberg, Saul H.,Sham, Hing L.,Sowin, Thomas J.,Lin, Nan-horng
, p. 3618 - 3623 (2007)
A study on substitutions at the four open positions on the phenyl ring of the 1,4-dihydroindeno[1,2-c]pyrazoles as potent CHK-1 inhibitors is described. Bis-substitution at both the 6- and 7-positions led to inhibitors with IC50 values below 0.
