100276-74-2

Upstream product

• 100276-63-9 ethyl 1-amino-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate 
• 100276-62-8 6,7,8-Trifluor-1,4-dihydro-1-(isopropylidenamino)-4-oxo-3-chinolincarbonsaeure-ethylester 
• 100276-61-7 3-(Isopropylidenhydrazino)-2-(2,3,4,5-tetrafluorbenzoyl)acrylsaeure-ethylester 
• 94714-58-6 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 

Relevant academic research and scientific papers

Cycloaracylation of Enamines,II. - Synthesis of 1-Amino-4-quinolone-3-carboxylic Acids

The 2-benzoyl-3-hydrazinoacrylic esters 3, 11, 17, and 23 are obtained by the reactions of 2-chloro-5-nitrobenzoyl chloride (1) with the enehydrazinocarboxylic esters 2 and 2-benzoyl-3-ethoxyacrylic esters 9 with hydrazine derivatives 10, 16, and 22.After cyclocondensation, the above esters afford 1-aminoquinolonecarboxylic esters 4, 12, 18, and 24, which are hydrolyzed to give the corresponding 1-aminoquinolonecarboxylic acids 5, 13, 19, and 26.The 1-amino-7-haloquinolonecarboxylic acids 13a-f, 19a-f, and 26b react with aliphatic amines to afford 1,7-diaminoquinolonecarboxylic acids 30c-m, which possess a high level of bactericidal activity.