10028-24-7 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 10028-24-7 differently. You can refer to the following data:
1. solid
2. The USP 32 states that dibasic sodium phosphate is dried or
contains, 1, 2, 7, or 12 molecules of water of hydration.
Anhydrous dibasic sodium phosphate occurs as a white powder.
The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular
or caked salt that effloresces in warm, dry air. The dodecahydrate
occurs as strongly efflorescent, colorless or transparent crystals.
Uses
Different sources of media describe the Uses of 10028-24-7 differently. You can refer to the following data:
1. Laxative.
2. Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).
3. Sodium phosphate dibasic dihydrate has been used for isolating DNA and RNA from bacterial samples of human gastrointestinal (GI) tract.
Production Methods
Either bone phosphate (bone ash), obtained by heating bones to
whiteness, or the mineral phosphorite is used as a source of tribasic
calcium phosphate, which is the starting material in the industrial
production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with
sulfuric acid. This mixture is then leached with hot water and
neutralized with sodium carbonate, and dibasic sodium phosphate
is crystallized from the filtrate.
Definition
ChEBI: A hydrate that is the dihydrate form of disodium hydrogenphosphate
Pharmaceutical Applications
Dibasic sodium phosphate is used in a wide variety of pharmaceutical
formulations as a buffering agent and as a sequestering agent.
Therapeutically, dibasic sodium phosphate is used as a mild laxative
and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for
example as an emulsifier in processed cheese.
Biochem/physiol Actions
Sodium phosphate dibasic dehydrate is an important component of running buffer of denaturing gel electrophoresis.
Safety
Dibasic sodium phosphate is widely used as an excipient in
parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in
many physiological processes since it is the principal anion of
intracellular fluid. Most foods contain adequate amounts of
phosphate, making hypophosphatemia (phosphate deficiency)
virtually unknown except for certain disease states or in patients
receiving total parenteral nutrition. Treatment is usually by the oral
administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed
from the gastrointestinal tract, virtually all of it being excreted in the
urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously,
rectally, or in patients with renal failure, can cause
hyperphosphatemia that may lead to hypocalcemia or other severe
electrolyte imbalances. Adverse effects occur less frequently
following oral consumption, although phosphates act as mild saline
laxatives when administered orally or rectally. Consequently,
gastrointestinal disturbances including diarrhea, nausea, and
vomiting may occur following the use of dibasic sodium phosphate
as an excipient in oral formulations. However, the level of dibasic
sodium phosphate used as an excipient in a pharmaceutical
formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg
storage
The anhydrous form of dibasic sodium phosphate is hygroscopic.
When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its
water of crystallization; and at a dull-red heat (about 240℃) it is
converted into the pyrophosphate, Na4P2O7. Aqueous solutions of
dibasic sodium phosphate are stable and may be sterilized by
autoclaving.
The bulk material should be stored in an airtight container, in a
cool, dry place.
Incompatibilities
Dibasic sodium phosphate is incompatible with alkaloids, antipyrine,
chloral hydrate, lead acetate, pyrogallol, resorcinol and
calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble
calcium-phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted in Europe for use as a food additive.
Included in the FDA Inactive Ingredients Database (injections;
infusions; nasal, ophthalmic, oral, otic, topical, and vaginal
preparations). Included in nonparenteral and parenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 10028-24-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,2 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10028-24:
(7*1)+(6*0)+(5*0)+(4*2)+(3*8)+(2*2)+(1*4)=47
47 % 10 = 7
So 10028-24-7 is a valid CAS Registry Number.
InChI:InChI=1/2Na.H3O4P.2H2O/c;;1-5(2,3)4;;/h;;(H3,1,2,3,4);2*1H2/q2*+1;;;/p-2
