1002970-32-2Relevant academic research and scientific papers
PIPERAZINE DERIVATIVES AS MAGL INHIBITORS
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, (2019/05/02)
The invention provides new heterocyclic compounds having general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase
Montgomery, Justin I.,Toogood, Peter L.,Hutchings, Kim M.,Liu, Jia,Narasimhan, Lakshmi,Braden, Timothy,Dermyer, Michael R.,Kulynych, Angela D.,Smith, Yvonne D.,Warmus, Joseph S.,Taylor, Clarke
scheme or table, p. 665 - 669 (2009/08/07)
A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided.
