100305-93-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Isopropyl-2H-pyrazole-3-carbaldehyde is used as a reactant for the preparation of indazolones, which are modulators of TNF signaling. These indazolones have potential therapeutic applications in treating inflammatory diseases and conditions where TNF signaling plays a crucial role.
Used in Chemical Synthesis:
In the chemical industry, 2-Isopropyl-2H-pyrazole-3-carbaldehyde serves as an important intermediate for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a valuable building block in the development of new molecules with diverse applications.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 18952-87-9 1-isopropyl-1H-pyrazole 

Relevant academic research and scientific papers

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we report the discovery of our clinical candidate S64315, a selective small molecule inhibitor of Mcl-1. Starting from a fragment derived lead compound, we have conducted structure guided optimization that has led to a significant (3 log) improvement of target affinity as well as cellular potency. The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compounds against other members of the Bcl-2 family. During optimization, we have also established predictive PD markers of Mcl-1 inhibition and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer models. The preclinical candidate has drug-like properties that have enabled its development and entry into clinical trials.