100313-37-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4,4'-dimethoxybenzhydryl)-3-(ethoxycarbonyl)carbodiimide is used as a coupling reagent for the production of pharmaceuticals. Its ability to facilitate the formation of amide bonds between amino acids or peptides is essential in creating biologically active molecules, which are vital components of many drugs.
Used in Bioconjugation:
In the field of bioconjugation, 1-(4,4'-dimethoxybenzhydryl)-3-(ethoxycarbonyl)carbodiimide is used as a coupling agent to link biological molecules, such as proteins or nucleic acids, with other molecules like drugs or fluorescent tags. This process is crucial for the development of diagnostic tools, therapeutic agents, and research reagents.
Used in Research Laboratories:
1-(4,4'-dimethoxybenzhydryl)-3-(ethoxycarbonyl)carbodiimide is also used as a reagent in research laboratories for various chemical reactions. Its non-toxic and stable nature makes it a safe and reliable choice for scientists working with peptide synthesis and protein modification.

Upstream product

• 19293-62-0 p,p'-dimethoxybenzhydrylamine 
• 100313-33-5 1-(4,4'-dimethoxybenzhydryl)-3-(ethoxycarbonyl)thiourea 

Downstream Products

• 100313-41-5 5-<(4,4'-dimethoxybenzhydryl)amino>-1-(β-D-ribofuranosyl)imidazole-4-carboxamide 

Relevant academic research and scientific papers

A New and Efficient Synthesis of Guanosine

New methodology for the preparation of guanosine-type nucleoside analogues from o-amino carbamyl nucleoside precursors has been developed and is demonstrated by the three-step, high-yield synthesis of guanosine (16) from 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (1, AICA-riboside).Treatment of 1-(alkoxycarbonyl)-3-(arylmethyl)thioureas 8 with phosgene in the presence of triethylamine affords the highly electrophilic 1-(alkoxycarbonyl)-3-(arylmethyl)carbodiimide reagents 9 in high yield.These reagents are shown to condense with AICA-riboside readily at room temperature to afford N-acyl-N'-(arylmethyl)guanidino-substituted imidazole nucleoside derivatives.One of these derivatives, 5-(N-benzyl-N'-(ethoxycarbonyl)guanidino)-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (11a), is smoothly debenzylated with cyclohexene in the presence of Pd(0) to afford 5-(N-(ethoxycarbonyl)guanidino)-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (14).Prolonged heating of 14 in ethanol at reflux affords N-2-(ethoxycarbonyl)guanosine (15) in high yield.The ethoxycarbonyl protecting group of 15 is removed with concentrated NH4OH/pyridine to afford guanosine.This new methodology is much more efficient than those previously reported and should find application for the preparation of a wide variety of guanosine-type nucleoside analogues.