100316-87-8Relevant academic research and scientific papers
Synthesis of unsymmetrical ureas and S-thiocarbamates under catalyst-free conditions in a [BMIM]BF4 ionic liquid
Hosseinzadeh, Rahman,Tajbakhsh, Mahmood,Aghili, Nora
, p. 175 - 182 (2015)
Unsymmetrical ureas and Sthiocarbamates were prepared in good to excellent yields by direct condensation of phenylurea with amines and thiols in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) without the addition of any additives. The [BMIM]BF4 ionic liquid is a mild medium and can be recycled and reused several times.
An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives
Hosseinzadeh, Rahman,Sarrafi, Yaghoub,Aghili, Nora
, p. 1171 - 1174 (2010)
A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.
