100350-93-4Relevant academic research and scientific papers
A New Approach to Allylamines and Pyrrolidines
Gajda, Tadeusz,Zwierzak, Andrzej
, p. 992 - 1002 (2007/10/02)
The 1,4-adducts 3a-c and 4, readily available from the reaction between diethyl N,N-dichlorophosphoramidate (1) and 1,3-dienes, were found to be convenient precursors for the efficient synthesis of the δ-chloroallylamine hydrochlorides 5a-d and N-phosphorylated allylamines 6a-c and 7.The three-step transformation of 3a-c affords the cis-3,4-dibromopyrrolidine hydrochlorides 10a-c.The preparation of the 2,5-dihydro-1H-pyrrole hydrochlorides 11a-c and trans-3,4-dibromopyrrolidine hydrochlorides 13a-c is also described.The stereochemistry of the reaction is studied.
