1003565-44-3

Upstream product

• 1003565-43-2 N-(7-amino-1,2,3,4-tetrahydronaphthalen-2-yl)-N-[2-(4-phenylpiperazin-1-yl)ethyl]propionamide 
• 1434078-93-9 2-((7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-1-(4-phenylpiperazin-1-yl)ethanone 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 1434078-85-9 ethyl 2-((7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)acetate 
• 1434078-82-6 ethyl 2-(propyl(1,2,3,4-tetrahydronaphthalen-2-yl)amino)acetate 
• 321864-80-6 C₁₃H₁₇N 
• 19485-87-1 2-(R,S)-Propylamino-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 1003565-45-4 8-[(2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino]-6,7,8,9-tetrahydro-1H-benzo[e]indole-1,2(3H)-dione 
• 1449331-25-2 C₃₁H₃₉ClN₄O₂S 
• 1434078-79-1 C₃₂H₃₉F₃N₄O₂S 
• 1434126-69-8 C₃₂H₄₀N₄O 
• 1434126-71-2 C₃₂H₄₂N₄O₂S 
• 1434126-72-3 C₃₂H₄₂N₄O₃S 
• 1434126-70-1 C₂₇H₃₈N₄O 
• 1434078-99-5 N⁷-(2,2-diethoxyethyl)-N²-(2-(4-phenylpiperazin-1-yl)ethyl)-N²-propyl-1,2,3,4-tetrahydronaphthalene-2,7-diamine 
• 1434126-68-7 C₂₇H₃₆N₄ 
• 1434079-00-1 2,2,2-trifluoro-1-(7-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydro-1H-benzo[f]indol-1-yl)ethanone 

Relevant academic research and scientific papers

Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-1-ol/-2-amino versions: Impact on functional activity and selectivity for dopamine D2/D3 receptors

The goal of the present study was to explore, in our previously developed hybrid template, the effect of introduction of additional heterocyclic rings (mimicking catechol hydroxyl groups as bioisosteric replacement) on selectivity and affinity for the Ds

Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2- ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration

This paper describes an extended structure-activity relationships study of aminotetralin-piperazine-based hybrid molecules developed earlier for dopamine D2/D3 receptors. Various analogues as positional isomers have been developed where location of the ph