1003580-86-6 Usage
General Description
S3I-M2001 is a small molecule inhibitor that specifically targets signal transducer and activator of transcription 3 (STAT3) signaling pathways. It has been shown to inhibit the activation, dimerization, and nuclear translocation of STAT3, leading to the downregulation of STAT3-regulated gene expression. S3I-M2001 has demonstrated potential as a therapeutic agent for the treatment of various cancers, as well as other inflammatory and autoimmune diseases that are associated with dysregulated STAT3 signaling. Its ability to selectively interfere with the activity of STAT3 makes it a promising candidate for the development of targeted therapies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1003580-86-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,5,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1003580-86:
(9*1)+(8*0)+(7*0)+(6*3)+(5*5)+(4*8)+(3*0)+(2*8)+(1*6)=106
106 % 10 = 6
So 1003580-86-6 is a valid CAS Registry Number.
1003580-86-6Relevant articles and documents
INHIBITORS OF STAT3
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Page/Page column 8, (2010/04/25)
Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.
