100360-57-4

Upstream product

• 1633-78-9 6-mercapto-1-hexanol 
• 76-83-5 trityl chloride 
• 4286-55-9 1-bromo-6-hexanol 
• 3695-77-0 triphenylmethanethiol 

Downstream Products

• 154509-85-0 6-S-trityl-6-mercapto-1-hexyl benzoate 
• 154509-86-1 6--6-mercapto-1-hexanol 
• 1292765-41-3 6-(tritylthio)hexyl methanesulphonate 
• 1292765-46-8 C₁₅H₂₅NS 
• 1456530-32-7 6-tritylthio-1-p-toluenesulfonylhexane 
• 1456530-36-1 C₄₀H₄₆F₁₂O₈S 
• 1456530-34-9 C₃₃H₃₂F₁₂O₅S 

Relevant academic research and scientific papers

Prodrug comprising a drug-linker conjugate

The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising a drug linker conjugate D-L, wherein -D is an amine containing biologically active moiety; and -L is a non-biologically active linker moiety -L 1 represented by formula (I), wherein the dashed line indicates the attachment to the amine of the biologically active moiety and wherein R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , X, X 1 , X 2 , X 3 have the meaning as indicated in the description and the claims and wherein L 1 is substituted with one to four groups L 2 -Z and optionally further substituted, provided that the hydrogen marked with the asterisk in formula (I) is not replaced by a substituent; wherein L 2 is a single chemical bond or a spacer; and Z is a carrier group and wherein D-H is a polypeptide selected from the group of polypeptides consisting of exendins, glucagon, glucagon-like peptides and insulins. The invention also relates pharmaceutical composition comprising said prodrugs and their use as medicaments.

CELL-PENETRATING, GUANIDINIUM-RICH OLIGOPHOSPHOTRIESTERS FOR DRUG AND PROBE DELIVERY

Guanidinium-rich oligophosphotriesters transporter compounds and methods of making and using the same are provided. Also provided are pharmaceutical compositions that include the subject transporter compounds, where the transporter can be joined to a carg

Carrier-linked carbamate prodrug linkers

The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.

Gold nanoparticles protected by fluorinated ligands for 19F MRI

Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for 19F MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together with their ability to bind hydrophobic molecules allowing for a potential combination of targeting, delivery and imaging features. The Royal Society of Chemistry 2013.

Microwave assisted synthesis of S-trityl and S-acylmercaptoalkanols, nucleosides and their deprotection

Simple and high yielding methods for the synthesis and deprotection of S-trityl and S-acylhexanols and appropriately protected 2'-deoxynucleosides in solvent and dry media conditions are described which occur under mild conditions using microwave irradiation.