1003608-97-6Relevant academic research and scientific papers
Synthesis of the EF-ring of ciguatoxin 3C based on the [2,3]-wittig rearrangement and ring-closing olefin metathesis
Goto, Akiyoshi,Fujiwara, Kenshu,Kawai, Ayako,Kawai, Hidetoshi,Suzuki, Takanori
, p. 5373 - 5376 (2008/09/17)
The EF-ring segment of Ciguatoxin 3C, a causative toxin of ciguatera fish poisoning, was synthesized in three major steps: 1,4-addition for the C20O-C27 bond connection, chirality transferring anti selective [2,3]-Wittig rearrangement for the construction of the anti-2-hydroxyalkyl ether part, and ring-closing olefin metathesis for the F-ring formation.
