10038-41-2

Upstream product

• 10038-40-1 [oxybis(2,1-phenylene)]dimethanol 
• 32852-70-3 2,2'-oxy-di-benzoyl chloride 
• 37424-29-6 2,2'-oxybis(benzoic acid) 
• 31680-22-5 2,2'-Oxybisbenzoesaeure-dimethylester 
• 4731-34-4 2,2'-dimethyldiphenyl ether 
• 101-84-8 diphenylether 
• 95-48-7 ortho-cresol 
• 446-52-6 2-Fluorobenzaldehyde 
• 90-02-8 salicylaldehyde 
• 49590-51-4 2,2'-oxybis(benzaldehyde) 

Downstream Products

• 42916-32-5 11,23-dibenzyl-11,12,23,24-tetrahydro-10H,22H-5,17-dioxa-11,23-diaza-tetrabenzo[a,d,i,l]cyclohexadecene 
• 32636-07-0 6-benzyl-6,7-dihydro-5H-dibenzo[b,g][1,5]oxazocine 
• 79946-24-0 N,N'-dibenzoyl-dibenzo-(b,h)-tetrahydro-1,5,6-oxadiazonine 
• 79946-23-9 N,N'-di-(3,4,5-trimethoxybenzoyl)-dibenzo-(b,h)-tetrahydro-1,5,6-oxadiazonine 
• 79946-22-8 N,N'-dibenzenosulfonyldibenzo-(b,h)-tetrahydro-1,5,6-oxadiazonine 
• 79946-21-7 N,N'-ditosyldibenzo-(b,h)-tetrahydro-1,5,6-oxadiazonine 
• 132103-21-0 2,2'-oxybisbenzeneacetonitrile 
• 4731-34-4 2,2'-dimethyldiphenyl ether 
• 122603-80-9 2,2'-bis(aminomethyl)-diphenyl ether 
• 606936-80-5 2,2'-bis(diphenylphosphinomethyl)diphenyl ether 
• 1356966-99-8 O(C₆H₄CH₂SH)2 
• 1443037-55-5 C₉₈H₁₄₆OP₄ 

Relevant academic research and scientific papers

Gold(I) Complexes Stabilized by Nine- and Ten-Membered N-Heterocyclic Carbene Ligands

Nine- and ten-membered N-heterocyclic carbene (NHC) ligands have been developed and for the first time their gold(I) complexes were synthesized. The protonated NHC pro-ligands 2 a–h were prepared by the reaction of readily available N,N′-diarylformamidines with bis-electrophilic building blocks, followed by anion exchange. In situ deprotonation of the tetrafluoroborates 2 a–h with tBuOK in the presence of AuCl(SMe2) provided fast access to NHC-gold(I) complexes 3–10. These new NHC-gold(I) complexes show very good catalytic activity in a cycloisomerization reaction (0.1 mol % catalyst loading, up to 100 % conversion) and their solid-state structures reveal high steric hindrance around the metal atom (%Vbur up to 53.0) which is caused by their expanded-ring architecture.

Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors

Inhibition of intestinal brush border DMT1 offers a novel therapeutic approach to the prevention and treatment of disorders of iron overload. Several series of diaryl and tricyclic benzylisothiourea compounds as novel and potent DMT1 inhibitors were discovered from the original hit compound 1. These compounds demonstrated in vitro potency against DMT1, desirable cell permeability properties and a dose-dependent inhibition of iron uptake in an acute rat model of iron hyperabsorption. Tricyclic compounds increased the in vitro potency by up to 16-fold versus the original hit. Diaryl compounds 6b and 14a demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses. The diaryl and tricyclic compounds described in this report represent promising structural templates for further optimization.

Study on the intramolecular transannular chalcogen-tin interactions in dithiastannecine compounds

Dithiastannecine compounds of the type [{D(C6H 4CH2S)2}SnR1R2] with different donor atoms D were prepared, where D = O and R1 = R 2 = Ph (4a); R1 = Ph, Rsu

BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS

This invention is directed to compounds of formula (I): wherein m, n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.

BISPHOSPHINE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF

Bisphosphines represented by the general formula (I) wherein Ar1 and Ar2 each represents an arylene group which may be substituted; R1 and R2 each represents an alkyl group which may be substituted, or an aryl group which may be substituted, or R1 and R2 may combinedly form a ring together with the phosphorus atom bonded thereto; R3 and R4 each represents hydrogen atom or an alkyl group; and the carbon atoms each having R3 and R4 are bonded in positions ortho to the oxygen atom bonded to Ar1 and Ar2: process for production thereof; Group VIII metal complexes comprising said bisphosphines; and process for producing aldehydes, which comprises, on hydroformylation of ethylenically unsaturated compounds with carbon monoxide and hydrogen, using said Group VIII metal complexes.The hydroformylation of ethylenically unsaturated compounds according to the present invention can produce n-aldehydes at higher reaction rate and industrially more advantageously than with catalysts comprising conventional phosphines, while suppressing side reactions such as hydrogenation and isomerization.

Potential Antitumor Agents. 62. Structure Activity Relationships for Tricyclic Compounds Related to the Colon Tumor Active Drug 9-Oxo-9H-xanthene-4-acetic Acid

A series of tricyclic analogues of 9-oxo-9H-xanthene-4-acetic acid have been prepared and evaluated for their ability to cause homorrhagic necrosis in subcutaneously implanted colon 38 tumors in mice, in an effort to extend the structure-activity relation