100381-49-5

Basic information

• Product Name: 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one
• Synonyms: 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one
• CAS NO: 100381-49-5
• Molecular Weight: 214.267
• Mol File: 100381-49-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one(100381-49-5)
• EPA Substance Registry System: 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one(100381-49-5)

Safety Data

• Hazardous Substances Data: 100381-49-5(Hazardous Substances Data)

Usage

General Description

1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one is a chemical compound with the molecular formula C15H17N3O. It is a cyclic imide derivative that has a benzimidazolone core structure with a cyclohexene moiety attached to it. 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one has potential applications in the pharmaceutical and agricultural industries due to its diverse biological activities, including anti-inflammatory, antifungal, and anticancer properties. Research on this compound is ongoing to explore its therapeutic potential and possible uses in various fields.

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 3190-03-2 1,3-dihydrospiro[2H-benzimidazole-2,1'-cyclohexane] 
• 95-54-5 1,2-diamino-benzene 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Relevant articles and documents

Efficient and simple synthesis of novel 1,2,3-triazolyl-linked benzimidazolone, molecular docking and evaluation of their antimicrobial activity

In this study, a novel series of 1,2,3-triazolyl-benzimidazolone derivatives have been synthesized by click reaction of azides with benzimidazolones 2a–b. The latter compounds were prepared with excellent yields (85–97%), the structures of products were determined by spectral analysis. Then, the X-rays crystallographic analysis of compound 7a revealed the self-assembling properties. The new heterocycles were evaluated for their in?vitro antimicrobial activities against Gram-positive and Gram-negative bacteria and against fungi strains. The most tested synthesized compounds showed potent antibacterial and antifungal activities against all tested strains. The compound 6c was found to be the most active, particularly, against Aspergillus niger and Penicillium sp. with the same MIC and MBC of 0.0625 mg/mL. Furthermore, in silico molecular docking studies stipulated a sign of a good correlation between experimental activity and calculated binding affinity. According to the docking results, compound 6d showed minimum binding energy and can be considered as a good antimicrobial agent.

Microwave-assisted domino benzannulation of α-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones

The microwave irradiation of a series of 2-diazo-1,3-diketones in the presence of an o-phenylenediamine derivative triggered a domino Wolff rearrangement/nucleophilic addition/intramolecular imination sequence to provide a new synthetic entry to 1,3-dihydr-2H-1,5-benzodiazepin-2-ones, a class of molecules with important biological properties. The microwave-assisted reactions of 2-diazo-1,3-diones and o-phenylenediamines in the absence of additives furnished bi-and tricyclic 1,3-dihydro-2H-1,5-benzodiazepin-2-ones by a domino Wolff rearrangement/nucleophilic addition/intramolecular imination sequence with the formation of three new covalent bonds. This reaction is a new and complementary synthetic approach to a class of "drug-like" compounds.