1003840-84-3Relevant academic research and scientific papers
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: Discovery of click yanilloids and cannabinoids
Appendino, Giovanni,Bacchiega, Sara,Minassi, Alberto,Cascio, Maria Grazia,De Petrocellis, Luciano,Di Marzo, Vincenzo
, p. 9312 - 9315 (2008/12/22)
(Chemical Equation Presented) Fooling nature: The replacement of amide and alkene groups in a biological setting with the 1,2,3-triazole group led to the discovery of compounds with a unique vanilloid/cannabinoid mixed profile. For example, the natural amides (see picture, above) and their triazole mimics (below) exhibit similar agonistic (X = H) or antagonistic (X = I) activity towards the TRPV1 receptor; however, only the triazole derivatives also show cannabinomimetic activity.
