1003850-64-3 Usage
Derivative of isoindolinone
It is a modified version of the base compound isoindolinone, which is a heterocyclic compound with a unique ring structure.
4-fluorophenylmethyl group
The compound contains a 4-fluorophenylmethyl group, which is a phenyl group (a ring structure with 6 carbon atoms and 5 hydrogen atoms) attached to a methyl group (a single carbon atom with 3 hydrogen atoms) and a fluorine atom at the 4th position.
Two hydroxy groups
The compound has two hydroxy (OH) groups in its structure, which are functional groups consisting of an oxygen atom bonded to a hydrogen atom.
Dihydroxy derivative
It is a derivative of the base compound with two additional hydroxy groups, making it a dihydroxy compound.
Potential pharmaceutical applications
Due to its unique structure and properties, the compound may have potential applications in pharmaceutical research and development. However, further research is needed to determine its specific uses and effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1003850-64-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,8,5 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1003850-64:
(9*1)+(8*0)+(7*0)+(6*3)+(5*8)+(4*5)+(3*0)+(2*6)+(1*4)=103
103 % 10 = 3
So 1003850-64-3 is a valid CAS Registry Number.
1003850-64-3Relevant articles and documents
2,3-Dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors
Xue, Zhi Zhao,Semenova, Elena A.,Vu, B. Christie,Maddali, Kasthuraiah,Marchand, Christophe,Hughes, Stephen H.,Pommier, Yves,Burke Jr., Terrence R.
, p. 251 - 259 (2008)
The bis-salicylhydrazides class of HIV-1 integrase (IN) inhibitors has been postulated to function by metal chelation. However, members of this series exhibit potent inhibition only when Mn2+ is used as cofactor. The current study found that bis-aroylhydrazides could acquire inhibitory potency in Mg2+ using dihydroxybenzoyl substituents as both the right and left components of the hydrazide moiety. Employing a 2,3-dihydro-6,7-dihydroxy-1H- isoindol-1-one ring system as a conformationally constrained 2,3-dihydroxybenzoyl equivalent provided good selectivity for IN-catalyzed strand transfer versus the 3′-processing reactions as well as antiviral efficacy in cells using HIV-1 based vectors.
