1003863-36-2

Upstream product

• 857419-46-6 2-(chloromethyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine 
• 1003863-35-1 2-(azidomethyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine 

Relevant academic research and scientific papers

BIOFUNCTIONAL THIOPHENE MONOMERS

Disclosed herein are functionalized 3,4-alkylenedioxythiophene (ADOT+) monomers represented by a chemical formula (CR1R2)(CR3R4)(CR4R6)x02C4H2S, wherein x=0 or 1; wherein each of R1, R2, R3, R4, R5, and R6 is independently selected from hydrogen, a hydrocarbyl moiety, and a heteroatom-containing functional group; and wherein at least one of R1, R2, R3, R4, R5, and R6 comprises the heteroatom-containing functional group selected from an aldehyde, a maleimide, and their derivatives thereof. Also, disclosed herein are aldehyde derivatives represented by (AD0T-CH2-NH)PY and a a maleimide derivative represented by (AD0T-(CH2)q-N)pZ where p= 1-2 and each of Y and Z is a hydrocarbyl moiety or a biofunctional hydrocarbyl moiety. In an embodiment of the ADOT+ monomers, one of R1, R2, R3, R4, R5, and R6 is replaced by a direct bond to an amide group, an azide group, or an ester group of a biofunctional hydrocarbyl moiety. Also, disclosed herein are polymers and copolymers made therefrom.

Preparation method of conductive polymer material capable of specifically identifying tumor cells

The invention discloses a preparation method of a conductive polymer material capable of specifically identifying tumor cells. The preparation method is characterized by comprising the following steps: (1) in a nitrogen atmosphere, adding 28 ml of toluene, 1.36 g and 10.4 mmol of 3,4-dimethoxy thiophene, 2.60 g and 23.1 mmol of 3-chloro-1,2-propylene glycol and 0.16 g and 0.92 mmol of p-toluene sulfonic acid monohydrate into a double-neck flask, carrying out mixing, and carrying out a reaction for 24 hours at a temperature of 90 DEG C; and (2) evaporating the mixture in the step, and then carrying out column chromatography purification to obtain EDOT-Cl. The preparation method disclosed by the invention has the following advantages: the flexible conductive polymer material capable of specifically identifying tumor cells is synthesized, non-labeling of the tumor cells is realized, non-invasive specific recognition is achieved, and an effective means is provided for screening of malignant tumors, early diagnosis of cancers and instant diagnosis.

SUPEROLEOPHOBIC AND/OR SUPERHYDROPHOBIC MATERIAL, PROCESS FOR PREPARING SAME AND APPLICATIONS THEREOF

The invention relates to a multilayer superoleophobic and/or superhydrophobic material comprising: on the one hand, a first constituent that is a conductive substrate or a substrate that has previously been rendered conductive (1): the surface of which is modified by chemical and/or physical treatment (2) and that incorporates a first adhesion-promoting conductive layer (3); or that incorporates a first adhesion-promoting conductive layer (3); and, on the other hand, at least one other constituent that is a superoleophobic and/or superhydrophobic polymer or copolymer layer (4, 5 or 6) composed of one or more monomers based on an aromatic or heteroaromatic ring substituted by one or more fluorocarbon and/or hydrocarbon chains. It is characterized in that the various constituents of said material comply with an increasing hydrophobicity gradient between the first layer deposited on the conductive substrate or substrate previously rendered conductive (1) and the last layer of said material.

Synthesis of novel chiral l-leucine grafted PEDOT derivatives with excellent electrochromic performances

Two amino acid-functionalized poly(3,4-ethylenedioxythiophene) (PEDOT) derivatives, poly(N-(tert-butoxycarbonyl)-l-leucyl(3,4-ethylenedioxythiophene- 2′-yl)methylamide) (PEDOT-Boc-Leu) and poly(l-leucyl(3,4- ethylenedioxythiophene-2′-yl)methylamide) (PEDOT-Leu) were synthesized electrochemically via potentiostatic polymerization of corresponding monomers N-(tert-butoxycarbonyl)l-leucyl(3,4-ethylenedioxythiophene-2′-yl) methylamide (EDOT-Boc-Leu) and l-leucyl(3,4-ethylenedioxythiophene-2′-yl) methylamide (EDOT-Leu), which were synthesized by grafting Boc-l-leucine and l-leucine into a 3,4-ethylenedioxythiophene (EDOT) side chain. The electrochemical behaviors, structural characterization, circular dichroism, spectroscopic properties, surface morphology, electrochromic properties and thermal stabilities of PEDOT-Boc-Leu and PEDOT-Leu films were systematically investigated. These l-leucine grafted PEDOT derivatives displayed excellent reversible redox activities, rough and compact surface, and good thermal stability. The circular dichroism spectra suggested the chirality of these polymers. Importantly, the introduction of the l-leucine group enhanced the electrochromic properties of PEDOT and resulted in high contrast ratios (ΔT% = 49% at 600 nm for PEDOT-Boc-Leu) and high coloration efficiencies (431 cm2 C-1 at 960 nm for PEDOT-Leu). Satisfactory results implied that the obtained polymer films can probably be further developed in various applications, such as electrochromic devices, optical displays and chiral recognition.

DNA COMPLEXING AGENTS

The invention provides a compound of structure (I): wherein X is S, O or NRN, where RN is H or alkyl; L is a linker group; Q is a group capable of binding with dsDNA; G and G' are, independently, absent or have between 1 and 20 main chain atoms; FG is a functional moiety comprising at least one O or N atom or a transition metal complex; and R is selected from the group consisting of H, alkyl, alkoxy or OCRaRb coupled to an atom in L so as to form a six-membered ring. Ra and Rb are independently H or optionally substituted alkyl.