1003869-72-4

Upstream product

• 126410-47-7 [(S)-2-(4-benzyloxy-phenyl)-1-(R)-oxiranyl-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 1003889-13-1 C₁₉H₂₄N₂O₄S 
• 1003869-73-5 tert-butyl (S)-2-(4-methoxyphenyl)-1-((R)-oxiran-2-yl)ethylcarbamate 
• 1003870-01-6 C₁₆H₂₀F₃NO₆S 

Relevant academic research and scientific papers

ANTIVIRAL PROTEASE INHIBITORS

The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and /or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Inhibitors of aspartyl protease

The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.