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(S) N-[1-(4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1003875-34-0

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1003875-34-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1003875-34-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,8,7 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1003875-34:
(9*1)+(8*0)+(7*0)+(6*3)+(5*8)+(4*7)+(3*5)+(2*3)+(1*4)=120
120 % 10 = 0
So 1003875-34-0 is a valid CAS Registry Number.

1003875-34-0Downstream Products

1003875-34-0Relevant academic research and scientific papers

MORPHOLINYL AND PYRROLIDINYL ANALOGS

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Page/Page column 122, (2008/06/13)

The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles

McAtee, John J.,Dodson, Jason W.,Dowdell, Sarah E.,Erhard, Karl,Girard, Gerald R.,Goodman, Krista B.,Hilfiker, Mark A.,Jin, Jian,Sehon, Clark A.,Sha, Deyou,Shi, Dongchuan,Wang, Feng,Wang, Gren Z.,Wang, Ning,Wang, Yonghui,Viet, Andrew Q.,Yuan, Catherine C.K.,Zhang, Daohua,Aiyar, Nambi V.,Behm, David J.,Carballo, Luz H.,Evans, Christopher A.,Fries, Harvey E.,Nagilla, Rakesh,Roethke, Theresa J.,Xu, Xiaoping,Douglas, Stephen A.,Neeb, Michael J.

body text, p. 3716 - 3719 (2009/04/04)

Lead compound 1 was successfully redesigned to provide compounds with improved pharmacokinetic profiles for this series of human urotensin-II antagonists. Replacement of the 2-pyrrolidinylmethyl-3-phenyl-piperidine core of 1 with a substituted N-methyl-2-

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