100388-41-8

Basic information

• Product Name: 4-[2-(2-chloro-4-nitro-phenoxy)-ethyl]-morpholine
• Synonyms: 4-[2-(2-chloro-4-nitro-phenoxy)-ethyl]-morpholine
• CAS NO: 100388-41-8
• Molecular Weight: 286.715
• Mol File: 100388-41-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[2-(2-chloro-4-nitro-phenoxy)-ethyl]-morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2-chloro-4-nitro-phenoxy)-ethyl]-morpholine(100388-41-8)
• EPA Substance Registry System: 4-[2-(2-chloro-4-nitro-phenoxy)-ethyl]-morpholine(100388-41-8)

Safety Data

• Hazardous Substances Data: 100388-41-8(Hazardous Substances Data)

Upstream product

• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 110-91-8 morpholine 
• 619-08-9 2-chloro-4-nitrophenol 
• 3647-69-6 4-(2-chloroethyl)morpholine hydrochride 
• 3240-94-6 N-(2-chlorethyl)morpholine 

Downstream Products

• 1338251-29-8 1-[4'-(trifluoromethyl)phenyl]-4-[N-[3-chloro-4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole 
• 1338251-30-1 1-(2'-nitrophenyl)-4-[N-[3-chloro-4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole 
• 1338251-33-4 1-(2',4',6'-trichlorophenyl)-4-[N-[3-chloro-4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole 
• 1338251-34-5 1-(2'-chloro-4'-nitrophenyl)-4-[N-[3-chloro-4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole 
• 111271-83-1 [3-chloro-4-(2-morpholino-ethoxy)-phenyl]-carbamic acid ethyl ester; hydrochloride 
• 100248-82-6 [3-chloro-4-(2-morpholin-4-ylethoxy)phenyl]amine 

Relevant articles and documents

Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC)

Potential new EGFRT790M inhibitors comprised of structurally modified diphenylpyrimidine derivatives bearing a morpholine functionality (Mor-DPPYs) were used to improve the activity and selectivity of gefitinib-resistant non-small cell lung cancer (NSCLC) treatment. This led to the identification of inhibitor 10c, which displayed high activity against EGFRT790M/L858R kinase (IC50?=?0.71?nM) and repressed H1975?cell replication harboring EGFRT790M mutations at a concentration of 0.037?μM. Inhibitor 10c demonstrated high selectivity (SI?=?631.9) for T790M-containing EGFR mutants over wild type EGFR, suggesting that it will cause less side effects. Moreover, this compound also shows promising antitumor efficacy in a murine EGFRT790M/L858R-driven H1975 xenograft model without affecting body weight. This study provides new potential lead compounds for further development of anti-NSCLC drugs.

Synthesis and Biological Activity of Novel 1-Substituted Phenyl-4-[N-[(2'-morpholinothoxy)phenyl]aminomethyl]-1H-1,2,3-Triazoles

In an attempt to search for potent antifungal agents, a series of novel 1-substituted phenyl-4-[N-[(2'-morpholinothoxy)phenyl]aminomethyl]-1H-1,2,3-triazoles 5a-m was designed and synthesized via Huisgen cycloaddition reaction between various (2-morpholin