1003886-52-9Relevant academic research and scientific papers
Asymmetric synthesis of 1-(2-pyrrolyl)alkylamines by the addition of organometallic reagents to chiral 2-pyrroleimines
Alvaro, Giuseppe,Di Fabio, Romano,Gualandi, Andrea,Savoia, Diego
, p. 5573 - 5582 (2008/09/17)
The addition of organometallic (lithium, magnesium, zinc) reagents to 2-pyrroleimines derived from (S)-valinol and (S)-phenylglycinol gave N-substituted-1-(2-pyrrolyl)alkylamines with high yields and diastereoselectivities. The (S,S)-diastereomers were useful intermediates for the preparation of enantiopure 1-[1-(2-pyrrolyl)alkyl]aziridines by routine cyclization of the β-amino alcohol moiety and for the preparation of (S)-N-benzoyl 1-[1-(2-pyrrolyl)alkyl]amines and their N-substituted derivatives by oxidative cleavage of the chiral auxiliary. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
