1003887-67-9

Basic information

• Product Name: (1S)-1-[4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE
• Synonyms: (1S)-1-[4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE;Benzenemethanamine, α-ethyl-4-(trifluoromethyl)-, (αS)-
• CAS NO: 1003887-67-9
• Molecular Formula: C₁₀H₁₂F₃N
• Molecular Weight: 203.2
• Mol File: 1003887-67-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 224.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.86±0.10(Predicted)
• CAS DataBase Reference: (1S)-1-[4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-[4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(1003887-67-9)
• EPA Substance Registry System: (1S)-1-[4-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE(1003887-67-9)

Safety Data

• Hazardous Substances Data: 1003887-67-9(Hazardous Substances Data)

Usage

General Description

(S)-1-[4-(trifluoromethyl)phenyl]propylamine is a chemical compound with the molecular formula C10H13F3N. It is an amine derivative with a propyl chain and a trifluoromethylphenyl group. (S)-1-[4-(trifluoromethyl)phenyl]propylamine belongs to the class of organic compounds known as aralkylamines, which are a type of amine that contains an aromatic group attached to an alkyl group. (S)-1-[4-(trifluoromethyl)phenyl]propylamine may have various applications in the pharmaceutical and chemical industries, such as being used in the synthesis of other organic compounds or as a building block for the development of biologically active molecules. Additionally, it may have potential uses in research and development for its unique chemical and pharmacological properties.

Upstream product

• 67081-98-5 (+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol 
• 711-33-1 4-trifluoromethyl propiophenone 
• 1003887-66-8 (S)-2-(S)-1-[4-(trifluoromethyl)phenyl]propylamino-2-phenylethanol 

Downstream Products

• 1003887-68-0 (S)-1-(1-isocyanatopropyl)-4-(trifluoromethyl)benzene 

Relevant articles and documents

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.