100393-20-2Relevant articles and documents
Direct amide coupling of non-activated carboxylic acids and amines catalysed by zirconium(IV) chloride
Lundberg, Helena,Tinnis, Fredrik,Adolfsson, Hans
, p. 3822 - 3826 (2012)
Amidst the green: A green, mild and effective protocol for the direct formation of secondary and tertiary amides from non-activated carboxylic acids and amines in good to excellent yields by employing ZrCl4 as the catalyst is presented (see scheme). The amide coupling protocol proved to be suitable for scaled up syntheses, and the mild reaction conditions conserve the enantiopurity of chiral starting materials. Copyright
Amide formation using in situ activation of carboxylic acids with [Et 2NSF2]BF4
Mahe, Olivier,Desroches, Justine,Paquin, Jean-Francois
, p. 4325 - 4331 (2013/07/26)
The formation of amides through the in situ activation of carboxylic acids with [Et2NSF2]BF4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99 % yield. The reaction of hindered amines was also possible in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react without racemization. Copyright