100394-49-8Relevant academic research and scientific papers
Hybrid molecules of estrone: New compounds with potential antibacterial, antifungal, and antiproliferative activities
Adamec,Beckert,Weiss,Klimesova,Waisser,Moellmann,Kaustova,Buchta
, p. 2898 - 2906 (2007/10/03)
New hybrid molecules of estrone were synthesized as compounds indicating promising biological activity (antibacterial, antimycobacterial, antifungal, and antiproliferative). The prepared molecules contained various heterocyclic units (pyridine, benzylsulf
Antimycobacterial Agents. 1. Thio Analogues of Purine
Pathak, Ashish K.,Pathak, Vibha,Seitz, Lainne E.,Suling, William J.,Reynolds, Robert C.
, p. 273 - 276 (2007/10/03)
Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein showed moderate to good inhibitory activity. In particular, two purine analogues 9-(ethylcarboxymethyl)-6-(decylthio)-9H-purine (20) and 9-(ethylcarboxymethyl)-6-(dodecylthio)-9H-purine (21) exhibited MIC values of 1.56 and 0.78 μg/mL respectively against the Mtb H37Rv strain. N9-Substitution apparently enhances the antimycobacterial activity in the purine series described herein.
