100398-32-1

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethanone, 1-(2-chlorophenyl)-2-(2-pyridinyl)is utilized as a research compound for exploring its interactions with biological targets. Its unique structure allows it to potentially modulate various physiological pathways, offering a foundation for the development of new therapeutic agents.
Used in the Treatment of Various Diseases or Conditions:
While further research is necessary to fully elucidate its pharmacological properties, Ethanone, 1-(2-chlorophenyl)-2-(2-pyridinyl)may have applications in treating a range of diseases or conditions. Its ability to interact with specific targets could lead to the discovery of novel treatments for various medical needs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethanone, 1-(2-chlorophenyl)-2-(2-pyridinyl)serves as a key intermediate or building block in the synthesis of more complex molecules with therapeutic potential. Its structural features can be further modified to optimize its pharmacological properties and enhance its efficacy as a drug candidate.

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Relevant academic research and scientific papers

Substituted enaminones, their derivatives and uses thereof

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a

Chiroptical, Structural and Catalytic Properties of S-α-Methyl-benzylamines and their Rh(I) and Cu(I) Complexes

S-α-Methyl-benzylamines 15-21 and their Rh(I) complexes 22-28 are prepared and their chiroptical and conformational properties are studied.Free ligands are present as enamines in the solution and in the solid state, but are bound to Rh(I) in the imine form.The CD spectra confirm that complexation of 15-21 induces both structural change and strong conformational perturbations.The molecular structures in the crystal are reported for the chiral 1,5-bisnitrogen ligand 18, and its Rh perchlorate complex 25.The absolute conformation of the chromophore in 18 inverts on binding to Rh(I) in 25.The value of the torsional angle about C10-C9-C16-C21 bond (- 69.7 deg) in 18, which defines the twisted stilbene-like chromophore, turns for 25 into 75.0 deg.Chiral (S)-(-)-methylbenzyl subunit in 18 has a C1-N1-C9-C10 torsional angle of 175.2 deg, whereas on binding to Rh(I) in 25 this angle changes to -178.4 deg.The absolute conformation around the styrene-like arrangement of the bonds in 15-21 can be deduced from the strong positive Cotton effect at ca. 350 nm.Cyclopropanation of styrene with ethyl diazoacetate, in the presence of in situ generated Cu(I) complexes of chiral 1,5-bidentate ligands 15-21, yielded cis/trans 2-phenylcyclopropan-1-carboxylic acid ethylesters with 5-21percent e.e.Though generally low, the enantioselectivity was somewhat higher for ortho-(16-18) than for para-(19-21) substituted phenyl derivatives.