1004-74-6

Basic information

• Product Name: 2,4,5,6-TETRAAMINOPYRIMIDINE
• Synonyms: 2,4,5,6-tetraamino-pyrimidin;2,4,5,6-tetraaminopyrimidinesulphatemonohydrate;2,4,5,6-TETRAAMINOPYRIMIDINE;2,4,5,6-Tetraaminopyrimidiine;Pyrimidinetetramine;Pyrini-dinetetramine;2,4,5,6-Tetraaminopyrimidine ,97%;2,4,5,6-Pyrimidinetetraamine
• CAS NO: 1004-74-6
• Molecular Formula: C₄H₈N₆
• Molecular Weight: 140.15
• EINECS: 213-724-9
• Product Categories: APIs & Intermediate;Pyrimidine
• Mol File: 1004-74-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 563.918 °C at 760 mmHg
• Flash Point: 329.383 °C
• Appearance: /
• Density: 1.649 g/cm³
• Vapor Pressure: 1.64E-30mmHg at 25°C
• PKA: 6.97±0.10(Predicted)
• CAS DataBase Reference: 2,4,5,6-TETRAAMINOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5,6-TETRAAMINOPYRIMIDINE(1004-74-6)
• EPA Substance Registry System: 2,4,5,6-TETRAAMINOPYRIMIDINE(1004-74-6)

Safety Data

• Statements: 20/22
• Safety Statements: 36/37
• Hazardous Substances Data: 1004-74-6(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline powder

Synthesis Reference(s)

The Journal of Organic Chemistry, 16, p. 207, 1951 DOI: 10.1021/jo01142a007

InChI:InChI=1/C4H8N6.H2O4S.H2O/c5-1-2(6)9-4(8)10-3(1)7;1-5(2,3)4;/h5H2,(H6,6,7,8,9,10);(H2,1,2,3,4);1H2

Upstream product

• 1006-23-1 5-nitroso-2,4,6-triaminopyrimidine 
• 7647-01-0 hydrogenchloride 
• 24867-36-5 5-nitropyrimidine-2,4,6-triamine 

Downstream Products

• 7598-40-5 [1,2,5]thiadiazolo[3,4-d]pyrimidine-5,7-diamine 
• 73978-41-3 2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride 
• 4215-07-0 7-methyl-2,4-diaminopteridine 
• 708-74-7 2,4-diamino-6-methylpteridine 
• 58570-80-2 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 39232-22-9 4-{[(Z)-2,4,6-Triamino-pyrimidin-5-ylimino]-methyl}-benzaldehyde 
• 39232-23-0 N-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 39232-20-7 2,4,6-triamino-5-benzylideneaminopyrimidine 
• 119406-50-7 N-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 39481-11-3 3-{[(Z)-2,4,6-Triamino-pyrimidin-5-ylimino]-methyl}-phenol 
• 39232-24-1 N-[1-(4-Diethylamino-phenyl)-meth-(Z)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 39232-25-2 N-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 119406-49-4 N-[1-(4-Iodo-phenyl)-meth-(Z)-ylidene]-pyrimidine-2,4,5,6-tetraamine 
• 119406-47-2 N-[1-(2-Nitro-phenyl)-meth-(Z)-ylidene]-pyrimidine-2,4,5,6-tetraamine 

Relevant articles and documents

Imidazopyridine- and purine-thioacetamide derivatives: Potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels. To study the (patho)physiological roles of NPP1 potent and selective inhibitors with drug-like properties are required. Therefore, a compound library was screened for NPP1 inhibitors using a colorimetric assay with p-nitrophenyl 5′-thymidine monophosphate (p-Nph-5′-TMP) as an artificial substrate. This led to the discovery of 2-(3H-imidazo[4,5-b]pyridin-2-ylthio)-N-(3,4-dimethoxyphenyl)acetamide (5a) as a hit compound with a Ki value of 217 nM. Subsequent structure-activity relationship studies led to the development of purine and imidazo[4,5-b]pyridine analogues with high inhibitory potency (Ki values of 5.00 nM and 29.6 nM, respectively) when assayed with p-Nph-5′-TMP as a substrate. Surprisingly, the compounds were significantly less potent when tested versus ATP as a substrate, with Ki values in the low micromolar range. A prototypic inhibitor was investigated for its mechanism of inhibition and found to be competitive versus both substrates.

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One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.