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10040-45-6

10040-45-6

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10040-45-6 Usage

Chemical Properties

Off-White Solid

Originator

Guttalax, De Angelini, Italy ,1967

Uses

Different sources of media describe the Uses of 10040-45-6 differently. You can refer to the following data:
1. Sodium picosulfate acts as a stimulant laxative by increasing the frequency and the force of peristalsis and promoting electrolyte and water retention in the colon. Sodium picosulfate is most often used as laxatives.
2. Sodium picosulfate is a stimulant laxative related to bis-acedyl; used for the treatment of constipation and for evaluation of the colon by stimulation bowel movements following hydrolysis by colon bacteria.

Therapeutic Function

Laxative

Check Digit Verification of cas no

The CAS Registry Mumber 10040-45-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,4 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10040-45:
(7*1)+(6*0)+(5*0)+(4*4)+(3*0)+(2*4)+(1*5)=36
36 % 10 = 6
So 10040-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2

10040-45-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001104)  Picosulfate for system suitability  European Pharmacopoeia (EP) Reference Standard

  • 10040-45-6

  • Y0001104

  • 1,880.19CNY

  • Detail

10040-45-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Picosulfate Sodium

1.2 Other means of identification

Product number -
Other names disodium,[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10040-45-6 SDS

10040-45-6Synthetic route

4,4'-(2-pyridylmethylene)diphenol
603-41-8

4,4'-(2-pyridylmethylene)diphenol

Guttalax
10040-45-6

Guttalax

Conditions
ConditionsYield
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 0 - 20℃; for 5h;
Stage #2: With sodium hydroxide Concentration; Cooling with ice;		86.4%
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 35 - 40℃; for 3h; Flow reactor;
Stage #2: With sodium hydroxide		59.9%
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 10 - 25℃; for 12h; Inert atmosphere; Large scale;
Stage #2: With water; sodium hydroxide at 0℃; pH=11; pH-value; Inert atmosphere; Large scale;		2.1 kg
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

Guttalax
10040-45-6

Guttalax

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale
1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale
2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale
3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale
3.2: 0 °C / pH 11 / Inert atmosphere; Large scale
View Scheme
ethyl-2-picolinate
2524-52-9

ethyl-2-picolinate

Guttalax
10040-45-6

Guttalax

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale
1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale
2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale
3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale
3.2: 0 °C / pH 11 / Inert atmosphere; Large scale
View Scheme
Guttalax
10040-45-6

Guttalax

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

C18H13NO8S2(2-)*2Na(1+)*C42H70O35

C18H13NO8S2(2-)*2Na(1+)*C42H70O35

Conditions
ConditionsYield
In water at 25℃;
Guttalax
10040-45-6

Guttalax

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

Conditions
ConditionsYield
With water at 40℃; for 730.5h; Temperature;
Guttalax
10040-45-6

Guttalax

A

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

4,4'-(2-pyridylmethylene)diphenol
603-41-8

4,4'-(2-pyridylmethylene)diphenol

Conditions
ConditionsYield
With water at 40℃; for 730.5h;
Guttalax
10040-45-6

Guttalax

A

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

4,4'-(2-pyridylmethylene)diphenol
603-41-8

4,4'-(2-pyridylmethylene)diphenol

C

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

Conditions
ConditionsYield
With water at 40℃; for 4383h; Temperature;
Guttalax
10040-45-6

Guttalax

A

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
51264-33-6

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

B

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

(hydroxy(pyridin-2-yl)methylene)bis(4,1-phenylene) bis(sulfate)

Conditions
ConditionsYield
With water at 40℃; for 2191.5h; pH=4.5; pH-value; Temperature;

10040-45-6Relevant articles and documents

Preparation method of sodium picosulfate

-

Paragraph 0040; 0043-0045; 0048-0050; 0053-0055; 0058; ..., (2021/09/15)

The invention belongs to the technical field of medicines, and relates to a preparation method of sodium picosulfate, in particular to condensation of pyridine -2 - formaldehyde and phenol under an acidic condition, and the obtained intermediate 4,4 ' - (2 - pyridinmethylene) - bisphenol uses sulfamic acid as a sulfonating agent. The method is relatively simple in process operation and high in sample purity.

A process for preparing sodium new method (by machine translation)

-

, (2019/04/30)

The invention relates to a method for preparing (V) indicated by the sodium of the method, the method comprises the following steps: (a) in formula (I) indicated by the 2 - picolinic ester as the starting material, as shown in formula (II) of 4 - halogenated phenyl ether in the formula (III) Grignard reaction indicated by the 4', 4" - dialkoxy diphenyl - (2 - pyridine) - methanol (compound III). (B) 4 ', 4 "- dialkoxy diphenyl - (2 - pyridine) - methanol (compound III) in the Lewis acid under the action of removing a water molecule and alkoxy alkyl, formula (IV) as shown by a 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane (compound IV). (C) 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane with chlorosulfuric acid in sulfuric acid esterification reaction, sodium hydroxide after treatment, to obtain crude sodium, by recrystallization to obtain high-purity sodium (compound V). The present invention provides a kind of existing technology with the different sodium new preparation method, the method is simple in operation, the atom economy is high, is suitable for industrial production. (by machine translation)

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