1004111-41-4Relevant academic research and scientific papers
Small-molecule inhibitors of islet amyloid polypeptide fibril formation
Mishra, Rajesh,Bulic, Bruno,Sellin, Daniel,Jha, Suman,Waldmann, Herbert,Winter, Roland
, p. 4679 - 4682 (2008)
(Chemical Equation Presented) Small and effective: The pathological aggregation of amylin (IAPP), which leads to type II diabetes mellitus, is effectively inhibited by small-molecule rhodanine-based inhibitors at nanomolar concentrations. The prevention o
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
Bulic, Bruno,Pickhardt, Marcus,Khlistunova, Inna,Biernat, Jacek,Mandelkow, Eva-Maria,Mandelkow, Eckhard,Waldmann, Herbert
, p. 9215 - 9219 (2008/12/22)
Breaking up the crowd: The pathological aggregation of tau protein correlates closely with the progression of Alzheimer's disease. Rhodanine-based inhibitors of tau aggregation (e.g. 1) have been identified, and it has been shown that tau aggregation in a
