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CAS

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100427-03-0

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 100427-03-0 Structure

  • Basic information

    1. Product Name: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester
    2. Synonyms:
    3. CAS NO:100427-03-0
    4. Molecular Formula:
    5. Molecular Weight: 466.919
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 100427-03-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester(100427-03-0)
    11. EPA Substance Registry System: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester(100427-03-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100427-03-0(Hazardous Substances Data)

100427-03-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 100427-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,2 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100427-03:
(8*1)+(7*0)+(6*0)+(5*4)+(4*2)+(3*7)+(2*0)+(1*3)=60
60 % 10 = 0
So 100427-03-0 is a valid CAS Registry Number.

100427-03-0Downstream Products

100427-03-0Relevant articles and documents

Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity

Leonardi, Amedeo,Motta, Gianni,Pennini, Renzo,Testa, Rodolfo,Sironi, Giorgio,Catto, Alberto,Cerri, Alberto,Zappa, Marco,Bianchi, Giorgio,Nardi, Dante

, p. 399 - 420 (2007/10/03)

A series of asymmetric 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates characterized by the presence of a 3,3-diphenylpropylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1,4- dihydropyridines binding site labelled by 3H-nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers to the whole series an elevated level of antihypertensive activity and a long duration of action, a structure-dependent modulation of the activity being found only in the subset characterized by the presence of a branched propylene bridge between the ester and the amino groups. The presence of the amino group is essential for oral activity. Out of this series, compound 9u (Rec 15/2375- lercanidipine) was selected for clinical development and obtained marketing authorization as an antihypertensive in several countries.

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