1004287-06-2Relevant academic research and scientific papers
A new versatile and diastereoselective synthesis of polysubstituted 2-oxopiperazines from naturally occurring amino acids
Reginato, Gianna,Di Credico, Barbara,Andreotti, Daniele,Mingardi, Anna,Paio, Alfredo,Donati, Daniele
, p. 2680 - 2688 (2008/09/16)
A highly stereoselective approach to 1,3,4,5- and 1,3,3′,4,5-polysubstituted 2-oxopiperazines is reported. The method is based on the synthetic elaboration of naturally occurring amino acids to obtain enantiomerically enriched C-5 substituted oxopiperazines, which are further functionalized at C-3 via enolate formation and reaction with electrophiles. Notably, the two nitrogens of the ring can be orthogonally protected.
