1004287-35-7Relevant academic research and scientific papers
Spirofungin A: Stereoselective synthesis and inhibition of isoleucyl-tRNA synthetase
Marjanovic, Jasmina,Kozmin, Sergey A.
, p. 8854 - 8857 (2007)
(Chemical Equation Presented) Lock it in: A temporary silicon-based configurational lock (see scheme) has enabled an efficient and fully diastereo-selective assembly of the spiroketal subunit of spirofungin A. This complex natural product was synthesized in 20 steps, including a rapid polyketide assembly based on the ring-opening metathesis of a cyclopropenone acetal. It was established that spirofungin A elicited notable anti-proliferative activity against several human cancer cell lines and selectively inhibited isoleucyl-tRNA synthetase in vitro.
