100430-65-7Relevant academic research and scientific papers
Dynamic Stereochemistry of Imines and Derivatives. 19. Mutarotation and E - Z Izomerization of Chiral Imines in Methanol Solution
Boyd, Derek R.,Jennings, W. Brian,Waring, Lionel C.
, p. 992 - 995 (1986)
NMR studies indicate that the origin of the mutarotation of optically active N--1-phenylethylamine (1) and N--1-phenylethylamine (2) in CD3OD solution is E - Z izomerization and not tautomerization to the ena
Preparation method of chiral amine compounds
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Paragraph 0021, (2018/09/13)
The invention discloses a preparation method of chiral amine compounds. The preparation method of the chiral amine compounds specifically comprises the following steps: adding ketone compounds and chiral auxiliary (S)-a-phenylethylamine or (R)-a-phenylethylamine to an organic solvent to prepare an imine intermediate under the action of a large-steric-hindrance boron catalyst and a water removing agent; adding a reducing agent to the imine intermediate without separation and purification, and preparing the chiral amine compounds with a one-pot method. By calculation, the product yield is 81%-96%, and the highest de value can reach 99%. Compared with the prior art, the use amount of the large-steric-hindrance boron catalyst in the method can be reduced to 0.1 mol%, use of the equivalent metal catalyst is avoided from the source, and the method has the characteristics of being simple to operate, mild in reaction condition, wide in substrate applicability, environmental friendly and the like, and has better application value and potential economic and social benefits.
