100440-40-2

Upstream product

• 594-45-6 ethanesulfonic acid 
• 65976-54-7 2-(2-chloro-6-nitro-anilino)-ethanol 
• 100440-41-3 2-chloro-6-nitro-N-(2-thiocyanatoethyl)-aniline 
• 100418-54-0 Methanesulfonic acid 2-(2-chloro-6-nitro-phenylamino)-ethyl ester 

Relevant academic research and scientific papers

The synthesis and some reactions OF 3-(2-aminophenyl)-2-iminothiazolidines. Ring closure of n-(2-thiocyanaoethyl,)-nphenylenediamines; thiazolidine vs. 3,1,6-benzothiadiazocine formation

When treated with strong acids, the N-(2-thiocyanatoethyl)-n-phenylenediamines (1g-1y) are cyclized exclusively to 3-(2-aninophen- yl)-2-iminothiazolidines (6) while the related tertiary amines (1a-1f) gave, under the same conditions, benzothiadiazocines

Iminothiazolidine derivatives

The invention relates to novel iminothiazolidine derivatives of the formula (I), STR1 wherein R1 and R3 represent, independently from each other, hydrogen or lower alkyl group, R3 is nitro or amino group, R stands for halo, lower alkyl, haloalkyl, nitro, amino, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl group, and n is 0, 1 or 2, and pharmaceutically acceptable acid addition salts thereof. The iminothiazolidine derivatives of the formula (I) possess valuable antidepressant, antiparkinsonic, antiepileptic and spasmolytic activities.